Chelsea return to the scene of their final heartbreak, while a former friend becomes foe for Arsenal.
Gunners reunited with Eduardo; Blues return to Moscow
Chelsea return to the scene of their UEFA Champions League final heartbreak in Tuesday's early kick-off, while a former friend becomes foe for Arsenal.
Elsewhere, European giants Real Madrid and AC Milan meet, Bayern Munich host Cluj, Roma welcome Basel, and Auxerre travel to Ajax.
Braga take on Partizan Belgrade, and Marseille see Slovakian outfit MSK Zilina arrive in France.
Chelsea return to the plastic pitch of the Luzhniki Stadium in Moscow for the first time since the agony of their rain-soaked penalty shoot-out defeat to Manchester United in the 2008 final.
Spartak Moscow are the opponents this season and Blues manager Carlo Ancelotti, who took charge in 2009, will hope that there is no hangover from the previous events as his side aim to maintain a 100 per cent record in Group F.
Marseille and
Zilina meet at the Stade Velodrome in the group's second match, with both sides desperate to register their first points after two previous defeats.
Like Chelsea,
Arsenal can make a huge stride towards the knockout stages if they take three points from
Shakhtar Donetsk at Emirates Stadium in Group H.
A win would move Arsene Wenger's side onto nine points, but former Gunners striker Eduardo, who suffered an infamous broken leg while playing for the English side in 2008, will be aiming to stop his ex-club after leaving this summer.
Braga and
Partizan Belgrade will want to remain in touch with the group's frontrunners and will therefore need to collect a first point of the campaign come the final whistle in Portugal.
Heavyweights
Real Madrid and
AC Milan clash at the Bernabeu, with former Inter Milan manager Jose Mourinho's Galacticos yet to experience anything less than victory in Group G.
Ajax and
Auxerre will know that they need to win in Holland if they are to stay on the coattails of the group's leaders.
Bayern Munich may have endured a difficult start to their Bundesliga campaign, but they have six points from two matches in Group E and last season's defeated finalists will want to maintain momentum against
Cluj.
Roma's domestic form has also been abysmal, however, Claudio Ranieri will know that the last 16 of Europe's premier club competition will be within reach if
Basel are defeated at Stadio Olimpico.
