Emerson dropped by Brazil
The Roma star, who has often been criticised when representing his country, will be replaced in the midfield engine room by 24-year-old Renato.
"It's a technical and tactical change," Parreira revealed after a training session.
"Playing at home, we have to go after the three points. Renato has played several matches and he's no longer a newcomer."
Brazil currently have seven points from three games, one more than Uruguay and the world champions were heavily criticised for Sunday's 1-1 draw with Peru for a lacklustre display in midfield.
Emerson has started all of Brazil's previous qualifiers but has subsequently been replaced by Renato in every game.