Oranje coach Dick Advocaat was forced to omit defenders Jaap Stam and Frank De Boer after they reported injuries, and Seedorf added to his troubles when taking a knock on Sunday.
The midfielder's form has been of the highest order in recent weeks, which prompted a return to the international fold, but he was forced off at half time of Milan's draw with Chievo.
It is believed Seedorf's injury is only minor, but serious enough to see his name scratched from the party to face France.
Wilfred Bouma is doubtful for the match with Les Bleus after aggravating a back injury at the weekend.
