Liverpool and Celtic both face tricky trips in the Champions League while Chelsea entertain Schalke.
Watch all Wednesday's games with Sky Sports
Liverpool and Celtic both face tricky away trips in Wednesday's UEFA Champions League programme while Chelsea entertain Schalke.
Don't forget that there are various ways you can follow the Champions League fare with
Sky Sports. For instance,
there is broadband streaming, while
skysports.com will be providing an in-depth service. You can also follow the action on your mobile.
The Reds are at
Besiktas looking for a first win in Group A while Celtic face a stern examination when they tackle Benfica in Group D.
Victory is vital for
Liverpool after a stuttering start to their European campaign and their chances of three much-needed points have not been helped by the absence of striker Fernando Torres.
Difficult
In spite of their memorable home triumph over Milan,
Celtic have found away wins difficult to come by and have only one point from 14 away Champions League trips to their name.
Celtic boss Gordon Strachan insists his 'priority is to win' in Lisbon but admits his side will be lacking in experience, with captain Stephen McManus facing a late fitness test.
The defender left the Old Firm derby at the weekend on a stretcher with an oxygen mask having suffered concussion.
Chelsea will be without injured skipper John Terry and fellow England defender Ashley Cole for the visit of
Schalke.
Avram Grant's side have bounced back well after being held by Norwegian minnows Rosenborg in their opening game.
Absence
Didier Drogba scored a superb winner as The Blues beat Group B's form team
Valencia 2-1 away last time out and will be looking to make home advantage count.
Elsewhere in Group B, the Spaniards will be favourites to see off
Rosenborg in spite of the likely absence of star striker David Villa who faces a late fitness test.
Liverpool's Group A conquerers
Marseille will be looking to continue their perfect start in UEFA Champions League Group A when they take on
Porto.
A win will take Erik Gerets' side five points clear at the top of the group but the French outfit will be without centre-back Julien Rodriguez for the game.
Celtic's other Group D rivals
Milan entertain surprise leaders
Shakhtar Donetsk.
The European champions are desperately in need of a win after their slip-up at Celtic Park but will be without banned goalkeeper Dida for the game.
The top two in Group C meet at the Bernabeu as
Real Madrid play host to
Olympiakos.
Real will have their work cut out to collect all three points against the Greeks with a number of players unavailable because of injury.
Fabio Cannavaro and Mahamadou Diarra are both out with knee trouble, while Gabriel Heinze and Arjen Robben have thigh problems.
Elsewhere in the group,
Werder Bremen host
Lazio with both sides looking to claim their first win.