Jonathan Morgan has left his role as Leicester City Women first-team manager and Emile Heskey will prepare the team for their next match.
Morgan guided the club to the Women's Super League for the first time last season after winning the Championship title
Leicester sit bottom of the WSL table having lost all eight of their games so far this season.
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"This club has been part of mine and my family's life for 12 years from when my sister Holly Morgan joined as a young player," said Morgan, who was appointed Leicester manager during the 2014/15 season.
"To have taken Leicester from the Midlands Division 1 to a FAWSL club gives me nothing but pride. Earning promotion last season in the manner we did will always be a memory I can share with the fans and the city.
"This season has been disappointing, with injuries contributing to a difficult start, but we haven't achieved the results we had hoped for."
Morgan, who signed a new contract in July, was named LMA Championship Manager of the Year following Leicester's success last season.
Morgan's assistant manager Michael Makoni and first-team coach Holly Morgan will also leave the club.
A Leicester statement said: "All three have played an important role in the development of LCFC Women, particularly since the club turned professional following its acquisition by King Power in August 2020.
"The football club would like to place on record its thanks to Jonathan for everything he has helped the club to achieve during his time as manager, which included promotion to the WSL."
Heskey, the former England and Leicester forward and current head of women's football development at Leicester, will oversee first-team training in preparation for Continental Cup tie against Manchester United on December 5.
An away fixture against league-leaders Arsenal in the WSL follows on December 12.