Uefa Cup holders Zenit St Petersburg crashed out, while Hamburg, PSG, Shakhtar Donetsk and Dynamo Kiev all progressed.
PSG, Hamburg, Udinese, Kiev, Shakhtar, all reach last eight.
Uefa Cup holders Zenit St Petersburg crashed out, while Hamburg, Shakhtar Donetsk and Dynamo Kiev both progressed.
Dick Advocaat's
Zenit saw their grip on the Uefa Cup slip despite earning a 1-0 win over Udinese as the Italians earned a 2-1 aggregate victory.
Trailing 2-0 from the first leg in Italy Zenit reduced the arrears on 34 minutes when Anatoliy Tymoschuk found the net.
However, they could not find a second goal to force the game into extra-time as Udinese booked their place in the quarter-finals.
2005 winners
CSKA Moscow were also dumped out at the last-16 stage after
Shakhtar Donetsk secured a 2-0 win in the second leg to go through 2-1 on aggregate.
Luis Fernandinho fired Shakhtar in front on 54 minutes when he converted from the penalty spot after he himself was felled by Pavel Mamaev inside the box.
Shaktar ensured their progression into the next round when Luiz Adriano grabbed a second goal 20 minutes from time.
Hamburg came from two goals down to beat
Galatasaray 3-2 in Istanbul to go through 4-3 on aggregate.
Galastasray appeared to be heading into the quarter-finals after taking a 2-0 lead afterv 50 minutes, but Hamburg fought back to stun the Turkish giants.
Former Liverpool man Harry Kewell gave Galatasaray the lead on 42 minutes when he converted from the penalty spot.
Another ex-Red Milan Baros doubled the advantage four minutes after the break with a clever finish over Frank Rost.
Hamburg drew themselves and went ahead in the tie on away goals with two quick-fire strikes in three minutes from Paolo Guerrero (57, 60).
The Germans made sure of their progression in the final minute when Ivica Olic raced onto David Jarolím's to score his seventh goal of this Uefa Cup campaign.
Paris Saint Germain booked their place in the last eight with a 1-0 win over
Sporting Braga to go through 1-0 on aggregate.
Substitute Guillaume Hoarau was the hero for the French side when he scored with virtually his first touch of the game when he headed home into an unguarded net after Eduardo could only parry Clement Chantome's free-kick.
Dynamo Kiev survived a scare before seeing off fellow Ukrainian outfit
Metalist Kharkiv after the game ended 3-3 on aggregate.
Trailing 1-0 from the first leg Metalist levelled the tie up just before the half hour mark when Valentyn Slyusar found the net from Walter Anibal Acevedo's free-kick.
The home side went in front in the tie for the first time on 56 minutes courtesy of Jackson Coelho's superb free-kick.
Kiev pulled a goal back on 68 minutes when Goran Sabljic converted Olexandr Aliyev's cross, but Metalist restored their lead in the tie just two minutes later as Walter Acevedo scored from close-range.
Kiev secured the crucial second away goal 11 minutes from time when the unfortunate Andriy Berezovchuk put through his own net.
