West Ham striker Andy Carroll is set to miss out against his former club Liverpool on Super Sunday after failing to recover in time from a groin injury, while Mark Noble is also absent.
Noble has undergone surgery on a long-standing abdominal issue, a condition which he has played on with for a number of weeks.
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Carroll, who joined Liverpool in 2011 before moving to the Hammers a year later, was seen as 50/50 for the Premier League game - live on Sky Sports 1 HD from 2pm - but Slaven Bilic has revealed he will not feature at the London Stadium.
"He tried to do it yesterday and the day before yesterday - it's nothing major," Bilic said, "but it is frustrating not to have him because you know what he means to us."
Liverpool - who sit third and have a one-point lead over Manchester City - know a win is crucial, especially when it comes to attracting new players says Jurgen Klopp.
"It's important - how it is always important - for the club. Everybody knows it's a lot of money in the Champions League, it's not only the sports challenge, even though it's really exciting, it's also the money you can earn and as a football club we have to do this too," he said.
Cheikhou Kouyate has also undergone surgery on a wrist injury, which he has had since the Africa Cup of Nations. Fellow midfielder Noble (abdominal) will not feature again this season and Carroll remains sidelined.
Liverpool will assess the fitness of Roberto Firmino and Lucas Leiva ahead of the trip to the London Stadium.
Daniel Sturridge and Adam Lallana could both return to boost the visitors' attacking options as they look to cement Champions League qualification.
West Ham have won their last two home Premier League meetings with Liverpool, their best run since winning three in a row between 1997 and 1999.
The Reds have kept one clean sheet in their last 10 Premier League visits to West Ham, a 3-0 victory in May 2009.
None of the last 11 Premier League meetings between these sides at West Ham have ended as a draw, with the Hammers winning four and Liverpool seven since a 1-1 draw in December 2001.
In all competitions, the Reds are winless in their last five games against West Ham, their worst run since February 1965 (also five without a win); they've never gone six without a win against them.
If Liverpool win at the London Stadium, it will be the 52nd different ground at which they've won a Premier League game, more than any other side (Arsenal and Manchester United next on 50).
The Reds have won their last three away games in the Premier League - they last had a longer run in April 2014 (six games).
The Hammers have kept three consecutive Premier League clean sheets at the London Stadium for the first time - they last kept four in a row at home in February 2010.
Six of West Ham's seven Premier League home wins this season have been against sides currently in the bottom half of the table - the only exception was their last home game against Spurs (1-0).
Liverpool have won three of their four Premier League games in London this season, drawing the other. The last time they remained unbeaten in the capital across an entire league season was in 1988-89.
Manuel Lanzini has found the net in five of his last eight Premier League home games.
It all depends on which West Ham turns up, whether it's the team from the last few months or the one who beat Tottenham last week. It's a big game for them because another win could wipe away the cobwebs at the London Stadium and help them feel much more positive about the place next year.
You just don't know with Liverpool against so-called lesser teams. I would probably fancy them more if they were going to Man City. There's something missing in these games and they need to sort that out if they want to push on.
PAUL PREDICTS: 1-1 (6/1 with Sky Bet)
West Ham are Sky Bet's 18/5 outsiders to win with Liverpool the odds-on favourites at 7/10 and the draw is 14/5. All four of Daniel Sturridge, Roberto Firmino, Philippe Coutinho and Divock Origi are priced at 9/2 at the head of a wide-open first goalscorer market, with Andy Carroll seen as the biggest threat for the home side at 13/2. Liverpool are 3/1 to finish outside of the top four and West Ham out to 4/1 to make it into the top half.