Jose Mourinho's Roma put themselves in the driving seat in their Europa League tie with a 2-0 first-leg win over Real Sociedad.
Arsenal have been drawn against Sporting Lisbon in the Europa League last 16, with Manchester United facing Real Betis.
Barcelona's lead over Real Madrid at the top of La Liga evaporated on after they were held to a 1-1 home draw in an ill-tempered clash with local rivals Espanyol.
Tammy Abraham finds the net for Roma but Jose Mourinho lashes out at an unnamed player, while Inter Milan thrash Bologna and Atletico Madrid lose again.
A controversial second-half penalty was the difference as Manchester United's Europa League campaign started with a 1-0 loss to Real Sociedad at Old Trafford.
Pierre-Emerick Aubameyang fired Barcelona back into second place in La Liga after a narrow victory at Real Sociedad.
PSG looked sluggish and apathetic as the Ligue 1 leaders slumped to a 3-0 defeat at Monaco, while Tammy Abraham scored twice in the Rome derby.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Clubs from across Europe showed their support for Ukraine as the line-up for the Europa League and Europa Conference League last-16 was finalised on Thursday.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff tie on Thursday.
Ahead of the 2021/22 Europa League knockout round play-offs, we bring you the state of play, upcoming fixtures and the schedule for the remainder of the tournament.
A 96th minute header from substitute Luuk De Jong saw Barcelona rescue a 2-2 draw away at city rivals Espanyol in LaLiga on Sunday.
Borussia Dortmund fought back from two goals down after a lacklustre start to beat Eintracht Frankfurt 3-2 and return some excitement to the Bundesliga title race.
A stunning late goal from 19-year-old substitute Nico gave Barcelona three precious points as they beat Elche 3-2 at the Nou Camp in La Liga on Saturday.
Moussa Diaby scored twice as Bayer Leverkusen romped to a 4-0 Europa League victory over Real Betis, while Lyon have qualified from Group A after beating Sparta Prague.
Luis Suarez's double rescued a point for Atletico Madrid, Inter and Juventus played out a goalless draw in Serie A, while Jose Mourinho was sent off for Roma.
Brighton goalkeeper Mat Ryan is close to signing for Real Sociedad after the clubs agreed an undisclosed fee.
A police officer has been found guilty of the manslaughter of former professional footballer Dalian Atkinson.
Atletico Madrid honed in on the La Liga title with a 2-1 win over Real Sociedad on Wednesday to move four points clear at the top of La Liga.
Data from the Taser used on ex-footballer Dalian Atkinson showed it was activated eight times for a total of more than 80 seconds, a jury has heard.