Man City will face Real Madrid in the Champions League quarter-finals while Arsenal were drawn against Bayern Munich.
Lautaro Martinez missed the crucial penalty for Inter Milan as Atletico Madrid claimed a shootout victory to move into the Champions League quarter-finals.
Mikel Arteta has hailed the "big step" Arsenal have taken in qualifying for the quarter-finals of the Champions League for the first time in 14 years.
Jadon Sancho and Marco Reus were on target as Borussia Dortmund secured a nervous 2-0 win over PSV Eindhoven and a place in the Champions League last eight.
David Raya was the hero, saving two spot-kicks as Arsenal beat Porto 4-2 on penalties to make to the Champions League last eight after their last-16 tie ended 1-1.
Arsenal sources have denied Mikel Arteta insulted Porto manager Sergio Conceicao's family in the aftermath of Tuesday's dramatic penalty shootout.
The UEFA coefficient rankings could see Scotland lose their automatic Champions League spot - but how might it all change?
Barcelona progressed to the Champions League quarter-finals with a 3-1 home victory over Napoli to secure a 4-2 aggregate win.
Manchester City eased their way into the quarter-finals of the Champions League with a 3-1 victory over Copenhagen to secure a 6-2 aggregate win.
Real Madrid were made to work for their place in the Champions League quarter-finals, edging past RB Leipzig 2-1 on aggregate after a 1-1 draw in their second leg.
Bayern Munich secured a comprehensive 3-0 victory over Lazio at Allianz Arena to overturned a 1-0 deficit from the first leg and reach the Champions League last eight.
Kylian Mbappe put his weekend controversy behind him to fire PSG into the Champions League quarter-finals with a double in a 4-1 aggregate win at Real Sociedad.
The Premier League are in pole position for an additional Champions League place next season.
FC Porto stunned a drab Arsenal with a wonderful last-minute winner from Galeno as the Portuguese side took a slender Champions League last-16 first-leg lead.
Victor Osimhen rescued Napoli a 1-1 draw against Barcelona in the first leg of their Champions League last-16 tie in his first appearance for the club since December.
Inter Milan will take a slender advantage into their Champions League last-16 second leg against Atletico Madrid after Marko Arnautovic secured a 1-0 home win.
Borussia Dortmund were denied a Champions League last-16 victory at PSV Eindhoven by a controversial penalty as the two sides drew 1-1.
Follow all the action from tonight's Champions League last-16, first-leg ties as Inter Milan host Atletico Madrid and PSV Eindhoven entertain Borussia Dortmund.
UK police say lessons haven't been learned after the mistreatment of Liverpool supporters during the 2022 Champions League final.
Five points off the pace in the Bundesliga, out of the DFB-Pokal and trailing Lazio in their Champions League tie - Bayern Munich are in crisis.