Sassuolo and Fiorentina had to settle for a point each from a thrilling 3-3 draw, while AC Milan and Torino played out a goalless draw.
Cristiano Ronaldo converted a penalty to cap a dominant 3-0 win for Juventus over Fiorentina on Saturday.
Napoli lost further ground on Serie A leaders Juventus after they could only manage a goalless draw at home to bottom club Chievo.
Inter Milan suffered their heaviest defeat of the season by losing 4-1 to Atalanta in Bergamo, days after drawing with Barcelona.
Relegation-threatened Empoli have fired head coach Aurelio Andreazzoli after a run of one win in 11 matches in Serie A this season.
Dries Mertens scored a hat-trick as Napoli trounced Empoli 5-1 to narrow the gap to Serie A leaders Juventus to three points.
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