Adam Lallana and Philippe Coutinho are both in line for starting spots as Liverpool host Southampton on Nissan Super Sunday.
The England midfielder made his return to action against Watford on Monday after five weeks on the sidelines, replacing the Brazilian playmaker who suffered a dead leg.
But with the latter expected to overcome his injury, the duo could start at Anfield as Jurgen Klopp looks for his first win against the Saints in the Premier League.
Southampton - who still have five games of the season to play - have already beaten Liverpool this season in the EFL Cup semi-finals, winning 2-0 on a two-legged aggregate in January.
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The Saints have also shut the Reds out in all three games they have played against them this season, including the reverse league fixture in November.
Although Lallana and Coutinho are in line for starts, Daniel Sturridge's fitness continues to be managed and he is likely to only be on the Liverpool bench again.
Sadio Mane (knee) and Jordan Henderson (foot) continue to be sidelined for the Reds, along with long-term absentee Danny Ings.
Charlie Austin could make a long-awaited Southampton return on Sunday, having been sidelined since dislocating his shoulder in the Saints' 1-1 Europa League home draw with Hapoel Be'er Sheva on December 8.
Jurgen Klopp hasn't won any of his three previous Premier League games against Southampton (D2 L1). Liverpool had won their previous three v Saints prior to his arrival.
Southampton have won just one of their last five visits to Anfield in the Premier League (D1 L3), 1-0 in September 2013 with a goal from current Liverpool player Dejan Lovren.
Klopp now has an identical record to Brendan Rodgers in his first 65 Premier League games in charge of Liverpool: W33 D18 L14, winning 117 points.
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Since Klopp first took charge of Liverpool in October 2015, there have been 208 goals scored in Premier League games involving the Reds - more than any other side.
Daniel Sturridge has played just 1316 minutes of Premier League football since Jurgen Klopp took over as Liverpool manager - just 22% of the possible minutes during this time and less than 17 other Liverpool players.
Even if Southampton win their remaining five Premier League matches this season, they'll still fall under their league points tally in 2015-16 (63) and 2014-15 (60) and would only be able to equal their tally in 2013-14 (56).
Manolo Gabbiadini scored four goals in his first three Premier League appearances (248 mins), but since then he's failed to score and attempted just one shot on target in 237 Premier League minutes (four apps).
Seven of Southampton's 11 Premier League wins in 2016-17 have come on a Sunday. In fact, only Manchester United (8) and Tottenham (8) have won more games played on a Sunday in the Premier League this season than Claude Puel's side.
The race for the top four is back in Liverpool's hands and that's all you can ask for at this stage of the season. I expect them to win this game easily.
Southampton are another team that are on holiday so I'm expecting a comfortable afternoon for Jurgen Klopp's side.
PAUL PREDICTS: 3-0 (11/1 with Sky Bet)
Liverpool are Sky Bet's 8/13 favourites with Southampton 17/4 while the draw is priced at 3/1. Jurgen Klopp's men are all well odds-on for a top-four finish, priced at 6/1 for them to fail to qualify for the Champions League. Roberto Firmino heads the first goalscorer betting at 4/1 while Manolo Gabbiadini is considered the visitors' main threat at 7/1 to net first