Arsenal will host holders Manchester City in the Carabao Cup quarter-finals, while Manchester United head to Everton, with dates and times for all four last-eight ties now confirmed.
Mikel Arteta, whose Arsenal side saw off Liverpool on penalties to reach the last eight, got the better of Guardiola in the FA Cup semi-finals last season en route to winning that trophy and the Spaniard will be hoping history can repeat itself against his fellow countryman in this competition.
Tottenham face an away trip to Championship side Stoke City, who knocked out last year's finalists Aston Villa, while Brentford will host Newcastle in the club's first League Cup quarter-final match.
All of the last-eight fixtures will be played in front of the Sky Sports cameras on December 22/23, with dates and kick-off times now confirmed.
- Arsenal sneak past Liverpool on penalties
- Sam Vokes sees Stoke past Villa
- Said Benrahma stars for Brentford
- All the Carabao Cup results
Carabao Cup quarter-finals live on Sky Sports
Tuesday December 22
Brentford vs Newcastle United, 5.30pm
Arsenal vs Manchester City, 8pm
Wednesday December 23
Stoke City vs Tottenham Hotspur, 5.30pm
Everton vs Manchester United, 8pm
Sky Sports pundit Jamie Redknapp:
"Great draws. The one that stands out is Pep Guardiola vs Mikel Arteta - Arsenal are in really good form. It depends on what teams are put out but anything can happen and at this stage you're really close to a major trophy. I've been very impressed with Arsenal and it's going to be a very good game against City. Arteta was smiling about the draw - they're good friends but he'll still want to win!"
"Everton are in good shape too with Dominic Calvert-Lewin in form. For Ole to get a trophy and quieten everyone down would be so important. And it's a good draw for Tottenham - even though they'd want to be at home.
"Brentford-Newcastle is a tough one to call but I wouldn't be surprised if Brentford were to edge that one."
Arteta gunning for trophy
Arsenal boss Mikel Arteta to Sky Sports after Liverpool victory:
"I'm really happy with the performance. The boys were exceptional. We controlled the spaces they like to have, we competed much better for first and second balls - the aggression was really high and put them under pressure.
"I was here, enjoying the victory a little bit - and now we have to play Man City! There are some tough teams now in the competition. It's a big challenge. We want to take every opportunity to win a trophy."