Steven Bergwijn scored twice in stoppage time for Tottenham to stage one of the craziest comebacks in Premier League history to beat Leicester 3-2.
Chelsea extended their winless Premier League run to four games and missed the chance to go second after drawing 1-1 with Brighton.
Ghana crashed out of the Africa Cup of Nations at the group stage after a shock 3-2 defeat to Comoros in which captain Andre Ayew was sent off.
Morocco twice came from behind to draw 2-2 with Gabon as both teams qualified from Group C for the knockout stages of the Africa Cup of Nations.
Goals from Fabinho, Alex Oxlade-Chamberlain and Takumi Minamino sealed a routine 3-0 win for Liverpool over Brentford, moving the Reds up to second.
Kate Longhurst's last-gasp header snatched a late 1-1 draw for 10-player West Ham Women at Tottenham Women, who missed the chance to go second in the WSL table.
Shannon O'Brien's second-half winner lifted Leicester Women off the bottom of the WSL table after beating Brighton Women 1-0 at the King Power Stadium.
Jack Harrison scored a superb hat-trick as depleted Leeds produced a stunning 3-2 win at West Ham to dent the hosts' Champions League hopes on Super Sunday.
Adama Traore came off the bench to score his first Premier League goal of the season as Wolves beat Southampton 3-1 at Molineux.
Joao Pedro's equaliser saw Newcastle once again punished for conceding late goals as Watford snatched a 1-1 draw and avoided dropping into the bottom three.
Norwich breathed life into their Premier League survival hopes as their 2-1 victory over Everton ended a six-match losing streak to heap more pressure on Rafael Benitez.
A superb goal from Kevin De Bruyne earned Man City a 1-0 win over Chelsea and moved them into a surely unassailable 13-point lead at the top of the table.
West Ham moved back into the Champions League places after sweeping aside rock-bottom Norwich 2-0 at the London Stadium in the Premier League on Wednesday.
Southampton hit four goals in a Premier League game for the first time this season as they thrashed Brentford 4-1 at St Mary's.
Sudan goalkeeper Ali Abou Achrine saved a late penalty to ensure they secured a 0-0 draw with Guinea-Bissau in Garoua on Tuesday.