Barcelona slumped to a 1-0 home defeat by Rayo Vallecano which pushed leaders Real Madrid a step closer to the La Liga title.
PSG looked sluggish and apathetic as the Ligue 1 leaders slumped to a 3-0 defeat at Monaco, while Tammy Abraham scored twice in the Rome derby.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff tie on Thursday.
Ahead of the 2021/22 Europa League knockout round play-offs, we bring you the state of play, upcoming fixtures and the schedule for the remainder of the tournament.
Olivier Giroud again showed why he can never be written off, scoring two late goals as AC Milan rallied to beat rivals Inter 2-1 and reignite Serie A title race.
The Copa del Rey derby match between Real Betis and Sevilla was suspended after a pole hurled from the stands hit Sevilla player Joan Jordan in the head on Saturday.
Jose Mourinho was left frustrated as Roma suffered a 3-1 defeat at AC Milan, plus a round-up of the rest of the action in Serie A on Thursday.
La Liga champions Atletico Madrid were stunned by Granada, losing 2-1 on Wednesday, while Napoli slipped to defeat against Spezia in Serie A.
Lionel Messi's first Ligue 1 goal for Paris Saint-Germain sealed their 3-1 victory over Nantes.
Moussa Diaby scored twice as Bayer Leverkusen romped to a 4-0 Europa League victory over Real Betis, while Lyon have qualified from Group A after beating Sparta Prague.
The great-grandson of former Italian fascist dictator Benito Mussolini has been named in the Lazio squad for the first time.
Goals from Memphis Depay, Luuk de Jong, and Ansu Fati helped ease the pressure on Barcelona head coach Ronald Koeman with a 3-0 win over Levante at the Nou Camp.
Prosecutors have opened an investigation into alleged racist chants by Lazio supporters directed at AC Milan midfielders Tiemoue Bakayoko and Franck Kessie.
Former Chelsea winger Pedro has completed a move from Roma to Lazio in what is the first transfer between the cross-city rivals in 40 years.
West Ham have confirmed they have agreed a deal to sell Felipe Anderson to Lazio for an undisclosed fee.
West Ham are in advanced talks to sell Felipe Anderson back to Lazio, three years after the midfielder left the Serie A club.
Maurizio Sarri, the former Chelsea and Juventus boss, has been appointed as Lazio's head coach, replacing Simone Inzaghi.
Inter Milan have appointed Lazio's Simone Inzaghi as their new manager, with the Italian signing a two-year deal to replace Antonio Conte.
Lazio revived their hopes of Champions League qualification and subjected AC Milan to a second consecutive Serie A defeat as Joaquin Correa scored twice in a 3-0 win.
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