Bayern Munich moved top of Champions League Group E after a 2-0 home win against AEK Athens on Wednesday.
Robert Lewandowski scored in each half, his first from the penalty spot, to lift the Germans above Ajax, who were held 1-1 by Benfica in Lisbon.
Jonas gave Benfica a half-time lead but Dusan Tadic's 61st-minute equaliser ensured Ajax remain unbeaten in the group, two points behind Bayern.
Manchester United's stirring comeback win in Group E over Juventus means they are two points ahead of Valencia, who registered their first group win, 3-1 against Swiss side Young Boys at the Mestalla Stadium.
Young Boys striker Roger Assale cancelled out Santi Mina's opener, but the Valencia forward fired his second just before half-time.
Carlos Soler doubled the advantage early in the second half and the visitors were reduced to 10 men with 13 minutes left when Sekou Sanogo was shown a straight red card for his challenge on Francis Coquelin.
Gabriel Jesus fired a hat-trick as Manchester City thrashed Shakhtar Donetsk 6-0 in Group F to move closer to the knockout phase.
Hoffenheim's stoppage-time equaliser in Lyon means City have not qualified for the knockout stages yet.
Hoffenheim hit back from 2-0 down after playing most of the second half with 10 men due to Kasim Adams' dismissal for two yellow cards.
First-half goals from Nabil Fekir and Tanguy Ndombele had put Lyon in control, but the Germans rallied to avoid defeat and elimination, with Andrej Kramaric and Pavel Kaderabek - in the second minute of added time - both on target.
Roma secured their third straight Group G win by beating 10-man CSKA Moscow in Russia where Lorenzo Pellegrini fired a second-half winner.
Kostas Manolas headed Roma into a fourth-minute lead and after Arnor Sigurdsson had equalised for the Russians early in the second half, Iceland team-mate Hordur Magnusson was sent off for his second yellow card.
Midfielder Pellegrini struck the winner three minutes later but neither Real nor the Italians, both on nine points, are yet guaranteed a place in the knockout stage.