Harry Kane will have a scan on his right ankle on Monday after suffering an injury in Tottenham's weekend win over Bournemouth.
Kane left the stadium on crutches, wearing a protective boot, and there is concern he could be on the sidelines for a while.
The England striker was taken off during Tottenham's 4-1 win over Bournemouth in the 34th minute after appearing to turn the ankle in a challenge by Cherries 'keeper Asmir Begovic, as he netted a goal which was disallowed for offside.
Kane was replaced by Erik Lamela after receiving treatment, and he hobbled around the touchline to the changing rooms accompanied by a Spurs physio.
Manager Mauricio Pochettino confirmed to Sky Sports reporter Greg Whelan at half-time that the injury was "in his right ankle, possibly ligaments, similar to the injury sustained against Sunderland early last season".
Kane spent nearly two months out between September and November 2016 with an injury to that right ankle before another two-and-a-half-week period out with the same issue between March and April 2017.
And at full-time, Pochettino said: "I am concerned. Until tomorrow (Monday) and the scan we cannot say nothing more.
"Of course I worry about him, his ankle. We hope it is not a massive issue for him and the team. We hope as quickly as possible he can recover and be available.
"But he's positive. He is always positive. He is happy with the victory of the team. If you're positive you start the injury return from today."
Dele Alli also came off late in the game with a knock but Pochettino said: "I don't believe it's a big issue. We need to manage him in the next week."
Tottenham travel to Swansea for an FA Cup quarter-final next Saturday, but their next Premier League game is not until April 1 when they face Chelsea at Stamford Bridge.
England have two friendlies coming up, away to the Netherlands on March 23 and at home to Italy on March 27, and Kane must be a major doubt for those two matches.