Sunderland midfielder Sebastian Larsson will serve a three-game ban after his appeal against his red card against Manchester United was rejected.
The Swedish player was dismissed for a tackle on Ander Herrera in the first half last Sunday at the Stadium of Light.
United were leading 1-0 at the time and went on to cruise to a 3-0 victory over David Moyes' side, who remain bottom of the table.
Sunderland appealed Craig Pawson's decision on Tuesday but the FA said it had been rejected.
Larsson is set to miss the games against West Ham, Middlesbrough and Bournemouth with Sunderland needing to win the majority of their remaining matches to survive.
Moyes had claimed after the United game that Larsson's tackle did not even merit a yellow card.
He said: "He gets the ball, he touches the ball. There's no contact at all, so it's not even a booking.
"What I don't want to do is in any way blame the referees because our position is where we are, we are bottom of the league. So let me make that clear first of all, it's nothing to do with referees.
"But I didn't think it was a good decision."