Atletico Madrid's season finally sparked into life as they won 4-0 away to Celta Vigo thanks to an Antoine Griezmann double on Saturday.
Diego Simeone's side opened with disappointing draws against Alaves and another promoted side, Leganes, and Atleti went in goalless at the interval at Balaidos.
However, midfielder Koke broke the deadlock in the 53rd minute after a good bit of set-up play from Griezmann.
The mercurial France forward then scored twice himself in the 73rd and 81st minutes, heading in crosses from Saul Niguez and Juanfran, before Angel Correa added a late fourth.
Early pace-setters Las Palmas suffered heartbreak away to Sevilla as what looked like being a third straight win ended in a 2-1 defeat.
Tana curled home a glorious goal for the Canary Islanders in the 16th minute and they would have been well worth a win at the Estadio Pizjuan as they presented the more coherent goal threat throughout.
However, Vitolo won a dubious penalty after a challenge from Pedro Bigas which Pablo Sarabia converted in the 89th minute and fellow substitute Carlos Fernandez bundled in the winner with the final kick of the game in the 94th minute.
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Villarreal got their campaign up and running with a 2-0 win away to Malaga.
Jaume Costa put them in front in the 33rd minute at La Rosaleda after good approach work from Rafael Santos Borre, and Nicola Sansone added a second 10 minutes later, moments after Malaga goalkeeper Carlos Kameni saved a Bruno Soriano penalty.