Edin Dzeko hit a 21-minute hat-trick as Roma took a 4-0 first-leg advantage in their Europa League last-32 tie against Villarreal.
Emerson gave the visitors the lead in the 32nd minute, with the former Man City striker getting his first goal in the 65th minute.
He added a second 14 minutes later before rounding off a fine performance from Dzeko with four minutes of normal time to play to see Roma firmly in the driving seat heading into the second leg next week.
It was a better night for Villarreal's La Liga rivals Athletic Bilbao, who beat Apoel Nicosia 3-2 at home.
Georgios Efrem gave the visitors the lead with 36 minutes on the clock but an own goal from Giorgos Merkis saw the Spanish side level heading into the break.
Aritz Aduriz scored just after the hour mark to see Bilbao ahead before Inaki Williams netted added a third 11 minutes later, but Giannis Gianniotas ensured it would be a nervy ending as he scored Apoel's second with 89 minutes gone but Bilabo held on to maintain their one-goal lead.
Elsewhere, Besiktas won 3-1 at Hapoel Be'er Sheva and Bundesliga side Schalke came away from a trip to PAOK Salonika in Greece with an impressive 3-0 victory.
Legia Warsaw played out a goalless draw at home to Ajax while Anderlecht beat Zenit St Petersburg 2-0 at the Constant Vanden Stock Stadium.
In Thursday's other earlier kick-offs, Alexandre Lacazette scored twice as Lyon won 4-1 at AZ Alkmaar.
Sparta Prague saw Ivory Coast forward Tiemoko Konate sent off for collecting two yellow cards in the first half as they went down 4-0 away to Rostov.
There was also a red card for FC Copenhagen substitute Jan Gregus during the closing moments of his side's 2-1 win at Ludogorets.
A late header from Takayuki Seto earned Astra Giurgiu a 2-2 draw against Genk.
Viktor Claesson's goal after five minutes was enough to give Krasnodar a 1-0 home win over Fenerbahce.
Fiorentina left Borussia Monchengladbach with a 1-0 victory, while Shakhtar Donetsk won at Celta Vigo by the same scoreline.
Olympiacos had Brazilian defender Bruno Viana sent off during the closing stages of their goalless draw against Osmanlispor.