Arsenal are wary of suffering more misery when they take on Sunderland, while Crawley Town and Stevenage will be dreaming of giant-killings.
Arsenal aim to avoid week to forget; Crawley and Stevenage target upsets
Arsenal are wary of suffering more misery when they take on Sunderland in the FA Cup, while Crawley Town and Stevenage will be dreaming of giant-killings against Stoke City and Tottenham Hotspur.
The fifth round also contains outings for Premier League clubs Liverpool, Chelsea, Everton, Norwich City and Bolton Wanderers.
Arsenal were on Wednesday humiliated in their UEFA Champions League last 16 first leg against AC Milan as they were hammered 4-0 at the San Siro in what was one of the English club's worst performances for several years.
The fallout from the horror show saw manager Arsene Wenger on Thursday reportedly go 'crazy' at his squad during training and players could well be fighting for their futures for the rest of the season.
A trip to
Sunderland on Saturday evening is therefore far from ideal for Arsenal following Martin O'Neill's much-publicised rejuvenation at the Stadium of Light.
But Wenger's men have inflicted one of the three defeats O'Neill has suffered as Sunderland boss after Thierry Henry's late goal grabbed a 2-1 win on Wearside last weekend.
The Gunners, though, have won only two of their last seven FA Cup ties away from home.
The romance of the FA Cup will on Sunday be fully evident in
Stoke's trip to League Two
Crawley.
In the space of four days, Tony Pulis' side will have gone from rubbing shoulders with the European elite and Spanish heavyweights of Valencia to a tricky domestic cup tie at Broadfield Stadium.
Crawley are the lowest ranked club left in this season's FA Cup and boss Steve Evans will be aspiring towards a piece of history against last season's defeated finalists.
Stoke, though, have won their last four FA Cup matches away from home, keeping a clean sheet in three of those games, and Pulis will not expect any complacency.
Romance
League One
Stevenage could on Sunday also cause an upset when they welcome
Tottenham to Broadhall Way.
England manager-elect Harry Redknapp will know he is now, more than ever, headline material whether he wins, loses or draws after what has been a dramatic 2012 to date.
Amid Tottenham's Premier League title challenge, the club's manager has been cleared of tax evasion and has also been installed as runaway favourite for the England job.
Stevenage, who have yet to concede an FA Cup goal this season, will aim to halt the Redknapp juggernaut, but Tottenham have not lost in the FA Cup to a lower division side since Leicester in 2006.
With a challenge for the top four in the Premier League looking far from certain, Carling Cup finalists
Liverpool want a cup double and will be confident ahead of Sunday's tie against
Brighton & Hove Albion at Anfield.
Striker Luis Suarez will be under scrutiny given his behaviour in last weekend's defeat by Manchester United and subsequent apology, and his club will be expecting a less controversial outing.
Brighton's Uruguayan manager, Gus Poyet, has defended his compatriot throughout the racism row with Patrice Evra, but any sentiment will be put on hold when revenge is in the air.
Liverpool in September knocked Poyet's Championship play-off hopefuls out of the Carling Cup and he will be determined to set the record straight in the first FA Cup meeting between the two clubs in 21 years.
Chelsea manager Andre Villas-
