Tottenham produced a scintillating second-half performance to beat Borussia Dortmund 3-0 in the first leg of their Champions League last-16 tie at Wembley.
Heung-Min Son scored for the fourth game in a row to put Spurs ahead in the 47th minute.
Jan Vertonghen then volleyed in from Serge Aurier's cross in the 83rd minute before substitute Fernando Llorente headed in from a corner (86).
Tottenham: Lloris (7), Aurier (8), Alderweireld (8), Sanchez (7), Foyth (7), Vertonghen (9), Winks (7), Sissoko (7), Eriksen (7), Lucas (7), Son (8)
Subs: Llorente (6), Lamela (N/A), Wanyama (N/A).
Dortmund: Burki (5), Hakimi (5), Zagadou (5), Toprak (5), Diallo (5), Witsel (5), Delaney (5), Dahoud (5), Sancho (5), Pulisic (5), Gotze (5)
Subs: Schmelzer (5), Guerreiro (5), Larsen (5)
Man of the match: Jan Vertonghen
Dortmund looked shell-shocked and now have a mountain to climb in the return leg on March 5.
The Bundesliga leaders had looked the brighter side in the first half but they could not match Spurs when they raised their level after half-time.
Son's goal - his ninth in 11 games against Dortmund - set the tone for a dominant finish from Mauricio Pochettino's side that has put them on the brink of the last eight for the first time since 2011.
Such a one-sided result in favour of Tottenham looked unlikely early in the game as Dortmund started positively.
Spurs did see an eighth-minute shot from Lucas Moura whistle just past the post, but they were fortunate not to fall behind when Juan Foyth lost the ball in his own box and Christian Pulisic failed to beat Lloris at the near post.
The lively Jadon Sancho asked questions of Tottenham's defence, but Dortmund could not find the final pass.
Thomas Delaney's shot from outside the box was palmed out by Hugo Lloris before Spurs started to threaten as Christian Eriksen fired over and then Roman Burki saved with an outstretched leg from Son.
Dortmund went close to breaking the deadlock late in the first half but Lloris produced a brilliant diving save to claw away a header from Dan-Axel Zagadou on the line.
Spurs looked a team transformed after half-time as they attacked with more vigour and intensity.
Son opened the scoring in the 47th minute when he volleyed in from Vertonghen's cross, before Vertonghen fired over after a driving run and then Eriksen shot at Burki.
Dortmund were pinned back inside their own half and Spurs added to their lead late in the game.
Juan Foyth, who hasn't played in the Premier League in 2019 and wasn't included in Spurs' squad for the Champions League group stages, started in a five-man defence along with Serge Aurier.
Dortmund were without Marco Reus and Paco Alcacer so Mario Gotze started as a false nine.
Vertonghen finished from Aurier's excellent cross before Llorente headed in from a corner to put Spurs in firm control of the tie.
Man of the match - Jan Vertonghen
The defender scored and assisted in the same game for only the second time in his Tottenham career. He pushed forward more in the second half which allowed Spurs to sustain attacks and also meant Sancho was not as effective.
Tottenham's next match is at Burnley on Saturday, January 23, live on Sky Sports. They then face Chelsea (Wednesday, February 27) and Arsenal (Saturday, March 2) before the return leg against Dortmund on Tuesday, March 5.