Serie A leaders Milan were stunned 2-0 by Spezia to give Inter the chance to leapfrog them, while Atletico Madrid went eight points clear in La Liga.
Inter Milan moved to the top of Serie A after winning 2-0 at Fiorentina while Bayern Munich went 10 points clear at the top of the Bundesliga.
Real Madrid suffered a huge dent to their La Liga title ambitions following a surprise 2-1 defeat by Levante.
Timothy Fosu-Mensah has landed in Germany to complete his move from Manchester United to Bayer Leverkusen.
Bayer Leverkusen are in talks to sign Timothy Fosu-Mensah from Manchester United - but face competition from Ajax.
Real Madrid moved top of La Liga after a 2-0 home win over Celta Vigo with Lucas Vazquez and Marco Asensio on the scoresheet.