ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Bottom club FC Twente boosted their Eredivisie survival hopes with a 2-0 home win over PEC Zwolle.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
Manchester City are closing in on the Premier League title, but who else is set for glory - and misery - around Europe?
Eredivisie leaders PSV Eindhoven returned to winning ways on Saturday evening with a 3-0 home victory over VVV Venlo.
Heracles clinched a third successive win to move into the top half of the Eredivisie as they hit back from a goal down to edge out Twente.
Ajax's hopes of winning the Eredivisie title suffered another setback as they were beaten 3-2 at Vitesse Arnhem on Sunday.
Ajax closed the gap on Eredivisie leaders PSV Eindhoven to five points with a 1-0 win at PEC Zwolle on Sunday.
Ajax reduced the gap to Eredivisie leaders PSV to seven points following a hard-fought 2-1 victory against FC Twente.
Leaders PSV Eindhoven registered their sixth successive Eredivisie victory as they defeated Excelsior to stay clear of Ajax.
Luuk de Jong scored a hat-trick as PSV Eindhoven moved 10 points clear at the top of the Eredivisie with a 4-0 thrashing of PEC Zwolle.
PSV Eindhoven extended their lead at the top of Eredivisie to eight points with a hard-fought 2-0 win at Twente.
Youness Mokhtar's early strike clinched PEC Zwolle a 1-0 home win against NAC Breda and kept them in touch with the Eredivisie's top three.
Eredivisie leaders PSV Eindhoven returned to winning ways as they beat 10-man ADO Den Haag 3-0 at the Philips Stadion.
AZ Alkmaar missed the chance to put more pressure on Eredivisie leaders PSV Eindhoven after having to settle for a 1-1 draw at Zwolle.
Ajax missed the chance to close the gap on league leaders PSV after conceding a last-gasp equaliser in a 3-3 draw at lowly FC Twente.
Stefan Thesker scored an injury-time own goal as Eredivisie leaders PSV Eindhoven moved eight points clear with a dramatic 4-3 win over FC Twente.
PEC Zwolle moved up to second in the Eredivisie after a 2-0 win at struggling NAC Breda on Saturday.
Rene Hake has stood down as FC Twente's head coach after a poor start to the season.
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