Zlatan Ibrahimovic, Ander Herrera are back for Man Utd as they host Everton in the Premier League on Tuesday, while Luke Shaw could also be in contention.
Ibrahimovic and Herrera have been suspended for the last few games, with striker Ibrahimovic banned for three matches after his altercation with Tyrone Mings, while Herrera was out for two games after being sent off in the FA Cup defeat to Chelsea.
Meanwhile, Shaw has linked up with the United squad ahead of the clash with Everton having held talks with Jose Mourinho on Monday.
Omitted from the 18-man squad to face West Brom on Saturday, the United boss afterwards launched a scathing attack on the left-back in which he questioned the 21-year-old's fitness and attitude.
But Shaw is now understood to have checked in with the United team at their hotel ahead of Tuesday's clash after 'clear-the-air' talks with Mourinho.
Mourinho's men will be looking to close the gap on local rivals and current fourth-placed side Manchester City, who they trail by five points, as well as going 20 Premier League games unbeaten.
Everton are just three points behind their midweek opponents in seventh place and could replace United in the table with a victory on Tuesday although they have played two fewer games.
Ronald Koeman will also be looking to become the first manager in Premier League history to win three consecutive away games at Old Trafford.
Along with Ibrahimovic and Herrera, Man Utd's record signing Paul Pogba, who has been absent for the last two games because of a hamstring injury, could be fit to return.
However, Juan Mata - who has undergone surgery on his groin - and defenders Phil Jones and Chris Smalling remain on the treatment table.
Everton look set to have the same squad and while ex-United midfielder Morgan Schneiderlin (calf) could be available come the weekend, he will remain sidelined for this game.
James McCarthy (hamstring), Ramiro Funes Mori (knee) and Seamus Coleman (broken leg) are long-term absentees while Koeman says Aaron Lennon is "not in a physical way to be part of the team".
Manchester United have lost just one of their last 23 home league meetings with Everton (W18 D4), losing 0-1 in December 2013 under David Moyes.
United have won 33 Premier League games against Everton, the second highest total for one club beating another in the competition (Man Utd 34 vs Aston Villa).
The Toffees have scored just eight goals in their last 12 league visits to Old Trafford, with four of these coming in a single game in April 2012 (4-4).
45 different players have scored a Premier League goal for Manchester United against Everton - only Chelsea have seen more against a single club in the competition (50 vs Spurs).
Anthony Martial has scored twice and assisted another two goals in four matches against Everton in all competitions, including a 90th-minute winner in the FA Cup semi-final last season.
Manchester United have drawn eight of their 15 league games at Old Trafford this season (W6 D1). It's the first time they've drawn eight home league games in a season since 1980/81 (11 draws).
Mourinho the same as Van Gaal?
Jose Mourinho's record bears a striking resemblance to Louis van Gaal's first season.
Romelu Lukaku has scored three goals in eight Premier League games against the current top six this season, compared to 18 goals in 21 appearances against the rest of the division.
Indeed, the Belgian striker has scored in just one of his 10 previous Premier League games against Man Utd - netting a hat-trick for West Brom at The Hawthorns in May 2013.
This is now Mourinho's (19 games) longest unbeaten run in the Premier League since October 2005 with Chelsea (40 games).
A few weeks ago everyone was talking about Everton being on the up, and then they go to Middlesbrough and draw 0-0. Then they get bigged up, go to Tottenham and are poor.
Then they get bigged up again, go to Liverpool and are poor. They are missing a few players, but I thought it was comfortable for Liverpool.
Sooner or later Man Utd are going to hit a few past a team. I think if Man Utd don't win this, all their eggs are in the Europa League basket.
PAUL PREDICTS: 3-1 (11/1 with Sky Bet)
Sky Bet make Manchester United the odds-on favourites at 8/15 to win at home to Everton. The Toffees are available at 15/2 to bounce back from their Merseyside derby defeat with victory at Old Trafford and the draw can be backed at 3/1. United haven't conceded a goal in their last two home games and a win to nil for Mourinho's men is on offer at 6/4.
Sky Bet's first goalscorer odds are headed by the returning Ibrahimovic at 11/4 and Pogba, also back for United, is available at 8/1. The top Everton contender is unsurprisingly Lukaku at 11/2.