The chairman of the Premier League, Gary Hoffman, will step down from the role at the end of January 2022.
Hoffman said in a statement: "It has been a privilege to lead the Premier League through the last two seasons - when the spirit of English football has been more important than ever.
"Now, I have decided the time is right for me to stand aside to allow new leadership to steer the League through its next exciting phase."
The news comes after a backlash from clubs over the league's handling of the Newcastle takeover, with the Premier League thanking Hoffman for his time in charge.
- April 2020: Hoffman named PL chairman
- Newcastle takeover completed as Ashley's 14-year spell ends
- Staveley's Newcastle vision - 'We want to win PL title'
"The Premier League is grateful to Gary for his committed service," a league statement read.
"He has led the league during the most challenging period in its history and leaves it in a stronger position than ever.
"The process of appointing a new chair will begin immediately."
Sky News reported on Tuesday that Hoffman was set to resign following a backlash from clubs over the Premier League's handling of the Saudi-led takeover of Newcastle United.
Concerns about the league's decision were reportedly raised at a meeting of the 20 member clubs in October.
The Premier League insisted that it had been given assurances from the Saudi Public Investment Fund that the Saudi state would not have control over the club, despite the Fund being overseen by Crown Prince Mohammed Bin Salman.
In the aftermath of the takeover, 18 clubs, with the exception of Newcastle and Manchester City, backed a motion to put in place a temporary ban on owner-related sponsorship.
A working group featuring representatives from eight Premier League clubs is drafting new rules around the issue and is expected to report back at the end of the month.
If the rules are approved, Newcastle director Amanda Staveley - who is on the working group - is hopeful the ban will be lifted.