In-form Liverpool man Sadio Mane will be joined by Wilfried Zaha, Riyad Mahrez and a number of other Premier League stars at the 2017 Africa Cup of Nations after the final squads were announced.
This year's edition of the biennial tournament gets underway in Gabon on January 14, and culminates with the final on February 5, meaning those called up could potentially miss up to four Premier League matches.
That could prove disruptive to a number of sides, perhaps most notably Leicester City, who have no less than three players, including Mahrez and Islam Slimani, involved in the Algeria and Ghana squads respectively; all will be unavailable during what could prove to be a crucial spell for the Foxes.
Stoke City, Sunderland, Watford and West Ham United also each have three players involved across the squads of various qualifiers and Arsene Wenger will be without Mohamed Elneny, who played in every single minute of Egypt's qualifying campaign on the road to their first appearance at the tournament since 2010. Gunners youngster Ismael Bennacer - who is 19 years old and yet to make his Premier League debut - has also been named in the Algeria squad.
Liverpool will be without Senegal's Mane, though they will have defender Joel Matip available for selection after he was one of seven players - including West Bromwich Albion defender Allan Nyom - to snub a Cameroon call-up earlier this month.
Merseyside rivals Everton lose Idrissa Gueye to the Senegal squad, but Yannick Bolasie will not travel after the £25m summer signing from Crystal Palace suffered a serious knee ligament injury earlier this month. Mali international Bakary Sako has been included in his country's squad despite seeing little action for the Eagles this term.
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Crystal Palace have two eligible players in their squad but Pape Souare is yet to recover from a broken thighbone he suffered in a car crash in September.
Manchester United's Eric Bailly is one of four top-flight players named by Michel Dussuyer in his Ivory Coast squad as they look to retain their title.
Eight Premier League teams are unaffected by the tournament in the shape of Burnley, Chelsea, Manchester City, Middlesbrough, Swansea, Tottenham Hotspur, Southampton and West Brom. Read on for the full list…
Mohamed Elneny (Egypt)
Max Gradel (Ivory Coast)
Bakary Sako (Mali), Wilfried Zaha (Ivory Coast),
Idrissa Gueye (Senegal)
Ahmed Elmohamady (Egypt), Dieumerci Mbokani (DR Congo)
Daniel Amartey (Ghana), Riyad Mahrez and Islam Slimani (Algeria)
Sadio Mane (Senegal)
Eric Bailly (Ivory Coast)
Wilfried Bony (Ivory Coast), Mame Biram Diouf (Senegal), Ramadan Sobhi (Egypt)
Wahbi Khazri (Tunisia), Lamine Kone (Ivory Coast), Didier Ndong (Gabon)
Adlene Guedioura (Algeria)
Andre Ayew (Ghana), Cheikou Kouyate (Senegal)