Real Madrid slumped to a miserable 1-0 home defeat to strugglers Levante.
Sunday's action from Spain was full of surprises as Barcelona and Sevilla could only draw, while Read Madrid fell to the first defeat in their history against Levante.
Barcelona were repeatedly frustrated by a resilient Osasuna side, as away day blues saw them return to Camp Nou with only a 0-0 stalemate for their efforts.
In the final five minutes Samuel Eto'o came on to make his return after a long-term absence through injury but the Cameroon international, like his team-mates, drew a blank.
Real Madrid slumped to a 1-0 home defeat to Levante that is sure to increase the pressure on underfire coach Fabio Capello.
In what was another disappointing display from the capital club, Real fell to defeat courtesy of Salva's 12th minute penalty on his debut.
In the second period they briefly rallied in hitting the bar through Miguel Angel Nieto and having what looked to be a clear penalty denied when Ruud van Nistelrooy was brought down in the box, but having left the field to a chorus of boos, the Madrid faithful made clear their thoughts.
Sevilla too were made to rue missed opportunities when they could only draw 0-0 with strugglers Real Sociedad.
The surprise title challengers were dominant throughout but were denied on numerous occasions by the Basque battlers.
Ezequiel Gavay's 7th minute strike was enough to secure Racing Santander a 1-0 win over Getafe, while Celta Vigo and Gimnastic De Terragona shared the spoils after a 1-1 stalemate.
Borja Oubina's effort gave the home side the lead but Gimnastic escaped with a point thanks to Javier Portillo's goal 13 minutes from time.
Recreativo enjoyed an impressive 2-1 victory over Villarreal which saw Sinama-Pongolle score the crucial second.
Juanme's 13th minute opener was added to by Sinama-Pongolle a minute after the break, with Jon Dahl Tomasson's goal for Villarreal proving to be nothing more than a consolation.
Real Betis were away day winners at Athletic Bilbao as they returned from their travels with a 2-1 win.
Robert De Pinho De Souza (18) and Fabrice Pancrate (76) put Betis in cruise control before Ismael Urzaiz's injury time penalty made for an anxious final stage.
Click below for individual match summaries
Athletic Bilbao 1-2 Real Betis
Celta Vigo 1-1 Gimnastic
Osasuna 0-0 Barcelona
Racing Santander 1-0 Getafe
Real Madrid 0-1 Levante
Recreativo Huelva 2-1 Villarreal
Sevilla 0-0 Real Sociedad
