Dominic-Calvert Lewin, Conor Coady and Danny Ings scored their first England goals as Gareth Southgate's side secured a 3-0 win over Wales in Thursday night's friendly at Wembley.
The in-form Calvert-Lewin, making his England debut after hitting nine goals in seven games for Everton, opened the scoring after 26 minutes when he headed home a Jack Grealish cross.
Wolves centre-back Coady doubled England's lead early in the second half, scoring his first goal in 112 games for club and country when he poked Kieran Trippier's free kick beyond Wayne Hennessey.
Ings, another starter in an experimental England line-up, then completed the scoring with a close-range overhead kick after substitute Tyrone Mings had headed a corner back across goal.
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Ings' goal capped a satisfying night for Southgate, whose preparations for the game were again disrupted when Jadon Sancho, Ben Chilwell and Tammy Abraham became the latest England players to breach coronavirus guidelines over the weekend.
England: Pope (7), Gomez (6), Coady (7), Keane (6), Trippier (7), Phillips (6), Winks (6), Saka (6), Grealish (8), Ings (7), Calvert-Lewin (8)
Subs: James (6), Mount (6), Ward-Prowse (n/a), Barnes (n/a), Maitland-Niles (n/a)
Wales: Hennessey (7), C Roberts (6), Rodon (6), Mepham (5), B Davies (6), Ampadu (5), Morrell (6), J Williams (6), T Roberts (6), Matondo (6), Moore (7)
Subs: N Williams (6), Cabango (5), Levitt (5), Vaulks (5), Gunter (n/a), Smith (n/a)
Man of the match: Dominic Calvert-Lewin
How new-look England overcame Wales
It was perhaps unsurprising, given that disruption, that Southgate's men made a disjointed start, with Wales seeing most of the ball in the opening stages despite being without Gareth Bale, Aaron Ramsey and David Brooks.
England's line-up only had 54 caps between them, but while some of his team-mates took time to settle into the game, mis-hitting passes and surrendering possession cheaply, Calvert-Lewin found his feet quickly.
The 23-year-old first threatened in the 13th minute, dribbling around Hennessey after latching onto an Ings pass on the right-hand side of the Wales box, then cutting the ball back across goal.
Wales were able to clear their lines on that occasion, however, and soon they were threatening at the other end, a poor defensive header from Bukayo Saka, another England debutant, falling to Kieffer Moore, who volleyed wastefully wide.
- Dominic Calvert-Lewin and Bukayo Saka made their England debuts, with Jack Grealish and Danny Ings handed their first starts in a new-look side which also included Nick Pope, Kalvin Phillips and Connor Coady.
- Wales boss Ryan Giggs, without Gareth Bale or Aaron Ramsey, handed Schalke winger Rabbi Matondo his first international start. Joe Rodon and Chris Mepham came into the defence, while Jonny Williams and Tyler Roberts also got the nod.
Wales were made to rue that missed opportunity a few minutes later, when Trippier, England's captain on the night, found Grealish on the right flank. The Aston Villa man, excellent on his first England start, darted away from Ethan Ampadu and picked out Calvert-Lewin with a precise delivery.
Wales tried to muster an immediate response, but Chris Mepham's header from Jonny Williams' corner was held by Nick Pope, and the Burnley goalkeeper sprinted off his line soon afterwards to bravely deny Moore, who was running through on goal.
Moore was proving a handful for England's three-man defence up until then, but he was forced off with an injury after the coming together with Pope and Wales rarely threatened after that.
Coady, making only his second appearance for England, got his goal just eight minutes after the break, dispatching Trippier's outswinging delivery with a deft finish at the far post.
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England continued to push forward, with Ings punishing more slack Wales marking to send an overhead kick beyond the despairing Hennessey from eight yards out.
It was the first time three players had scored their first England goals in the same game since 1963, and they would have made it four had Saka's deflected strike not been brilliantly kept out by Hennessey soon after Ings' goal.
By then, though, the damage was already done.
Southgate's options were depleted for this game. In addition to Sancho, Chilwell and Abraham being unavailable, Harry Kane was rested and Raheem Sterling had pulled out with an injury.
On this evidence, however, England have plenty of depth. Southgate was even able to give debuts to substitutes Reece James and Harvey Barnes in the second half.
Southgate hails Calvert-Lewin, Grealish
England manager Gareth Southgate was full of praise for Calvert-Lewin and Grealish after the game.
"Excellent," he said of Calvert-Lewin's performance. "Really, very good. I thought he had excellent presence. His runs are a threat, he presses well, and he obviously took his goal well.
"I thought he could be really pleased. He's an all-round centre-forward, and I've always liked his general play. It's the goals he's getting now that have made him another level of player."
On Grealish, he added: "I thought his work with the ball was very good. We know he draws those fouls, he's comfortable receiving in tight areas. Again, I thought it was a (full) debut that he can be really pleased with."
Giggs frustrated by Wales defending
"I'm obviously disappointed with the result," said Wales boss Ryan Giggs. "I thought up until the first goal we were in the game and probably the better team. We looked comfortable, but when you give teams like England easy goals, then you are going to get punished.
"They were bad goals to give away. You can get away with it, perhaps, with the lesser teams, but with the bigger teams, with the quality they have, you can't.
"It was a bit of a blow Kieffer coming off because set pieces both for and against, he's a big strength for us. So that was a blow, but you have to deal with crosses, which we didn't."
Match stats: England continue winning run
- England have won six consecutive matches against Wales for the first time since a run of seven between March 1908 and March 1914.
- Wales suffered their worst defeat against England since May 1973, also a 3-0 defeat.
- Three players all scored their first England goals in this game (Calvert-Lewin, Coady and Ings). It's the first time that's happened since June 1963 against Switzerland (Tony Kay, Johnny Byrne and Jimmy Melia).
- Dominic Calvert-Lewin became the 188th player to score on his England debut and the first Everton player to do so since Fred Pickering in 1964.
- Conor Coady ended a run of 111 games for club and country with a goal, scoring his first goal since April 2018 for Wolves vs Bolton in a Championship match. It was the first time he'd had two shots in a match since March 2017 for Wolves vs Reading.
- There were just 54 caps between the players in the England starting XI before kick-off, the fewest for an international since May 1980, when the XI for a game against Australia had just 46 caps between them.
- Atletico Madrid's Kieran Trippier captained England for the first time, becoming the first outfield player since David Beckham in June 2008 to captain England while playing for a non-English club.
Both sides now turn their focus to the UEFA Nations League. England face Belgium in Group A2 live on Sky Sports Football HD from 4.30pm on Sunday, with kick-off at 5pm, while Wales are up against the Republic of Ireland in Group B4, with coverage starting on Sky Sports Football HD at 1.30pm ahead of the 2pm kick-off.