Matty Longstaff scored on his Premier League debut as Newcastle piled more misery on Manchester United with a 1-0 victory at St James' Park on Super Sunday.
Adama Traore's second-half double helped Wolves stun Manchester City 2-0 to leave Liverpool eight points clear at the top heading into the international break.
The warning signs were there for City after a flat first-half performance but Nuno Espirito Santo's decision to move Traore through the middle was a masterstroke as the winger scored twice on the counter-attack (80 & 90+4).
David Luiz's early header proved enough for Arsenal to beat Bournemouth and move up to third in the Premier League.
The Brazilian netted his first Arsenal goal on nine minutes, guiding Nicolas Pepe's corner past Aaron Ramsdale, and in a game of few clear-cut chances, the Gunners held on.
Tammy Abraham and Mason Mount helped Chelsea to a comfortable 4-1 win over Southampton at St Mary's.
Abraham's lob opened the scoring after 17 minutes before Mount doubled Chelsea's lead with a close-range strike. Danny Ings' tap-in pulled one back for Southampton but N'Golo Kante restored the visitors' two-goal lead before half-time with a long-range deflected strike and Michy Batshuayi added a fourth late on.
James Milner scored a 95th-minute penalty to keep up Liverpool's winning run in extraordinary fashion with a 2-1 win over Leicester.
Milner stepped up to send Kasper Schmeichel the wrong way from the spot after Sadio Mane was fouled in the Leicester area by Marc Albrighton. The victory extended Liverpool's winning run to 17 Premier League games.
Aaron Connolly scored twice on his first Premier League start as Brighton increased the pressure building on Mauricio Pochettino, thrashing Tottenham 3-0 at the Amex Stadium.
Tottenham came into the game low on confidence already following their 7-2 midweek mauling at home to Bayern Munich in the Champions League, but their problems deepened in only the third minute when goalkeeper Hugo Lloris, who was subsequently stretchered from the field after suffering a nasty arm injury, gifted Neil Maupay Brighton's opener.
Aston Villa secured their first away points of the season with an emphatic 5-1 win over Norwich at Carrow Road.
Wesley put the visitors on course for victory with a first-half double.
Jeff Hendrick's 72nd-minute strike heaped further pressure on Marco Silva as Burnley secured a 1-0 win over 10-man Everton at Turf Moor.
Seamus Coleman was sent off for a second bookable offence (56) to hand the Clarets the initiative, and Hendrick met Ashley Westwood's corner to volley home the winner as Everton's weakness at set-pieces was once more exploited.
Watford remain bottom and without a win in the Premier League this season after a turgid 0-0 draw with Sheffield United.
Crystal Palace beat West Ham 2-1 and moved up to fourth in the Premier League after VAR overturned Jordan Ayew's disallowed goal late on at the London Stadium.
A sensational team goal from West Ham saw Sebastian Haller put the hosts ahead in the 54th minute but a Patrick van Aanholt penalty (63) levelled things after Declan Rice was penalised for handball.
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