Harry Kane was among four players who returned to the Tottenham side for a friendly against Norwich - but they lost 2-1 to the Premier League's basement club.
Kane was injured when the season was suspended due to coronavirus as well as Moussa Sissoko, Heung-Min Son and Steven Bergwijn - but they all played in the defeat at the Tottenham Hotspur Stadium.
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Kane has been out since New Year's Day and was sorely missed as Spurs' form nosedived before the pandemic, dropping seven points below fourth-placed Chelsea and four behind Manchester United, who they face on June 19 on their Premier League return live on Sky Sports.
In a game divided into four quarters of 30 minutes, Erik Lamela took the lead for Tottenham with a diving header, having been set up by Bergwijn. Kane also hit the crossbar early on and Serge Aurier also had a chance.
Dele Alli - suspended for the United game due his coronavirus social media post - came on with several others at half-time but Norwich struck twice late on through Josip Drmic and Mario Vrancic to boost their momentum as they look to avoid relegation in the run-in.
The Canaries are six points adrift of 17th-placed Watford and begin their quest for survival with a clash against fellow strugglers Southampton at Carrow Road next Friday.
Lloris: Spurs have no margin for error in CL pursuit
Hugo Lloris says Tottenham have no margin for error if they are to claim an improbable Champions League place when the Premier League season resumes.
"We have to be honest, we are not in a good position at the moment," the Frenchman said. "Four points to Manchester United, seven points to Chelsea.
"We don't have the right to lose games. Even more when you face a direct opponent like Manchester United. We are going to start again with a very important game, maybe a decisive game for the future.
"About the title, it's almost done, but for the fourth place, or the fifth place, there will be a big battle and for the relegation, it will be an even bigger battle.
"There is a lot to win and to lose in these nine games. It's the final sprint, you can win or lose everything."
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Watch the Premier League with Sky Sports
The Premier League 2019/20 season will provisionally restart on Wednesday, June 17 and Sky, the UK's leading football broadcaster, will make 25 games available 'free to air' - including Everton vs Liverpool on the first full weekend back - for everyone in the UK to enjoy.
Sky Sports will show 64 live Premier League games when the season resumes. In addition to the 39 matches already scheduled to be broadcast exclusively live on Sky Sports before the coronavirus interruption, 25 more matches will be available on both Sky Sports Premier League and Sky's free-to-air Pick channel, allowing the whole nation to be part of the return of live sport.
Free-to-watch highlights of every remaining Premier League game this season will be available from shortly after the full-time whistle on the Sky Sports website, Sky Sports App and Sky Sports Football YouTube channel.