Who will take the Man Utd v Liverpool bragging rights? Can Dele Alli net another double? We look at the weekend's Premier League questions.
After a weekend break for FA Cup action, the top flight returns on Saturday with some pulsating fixtures and three games live on Sky Sports.
It all kicks off when Tottenham host West Brom on Premier League Live from 11.30am, before six games kick off at 3pm on Saturday afternoon and then league leaders Chelsea travel to reigning champions Leicester for the evening fixture.
Then it is Merseyside v Manchester on Nissan Super Sunday as Everton host Manchester City at 1.30pm before Manchester United face rivals Liverpool at 4pm.
Live Premier League
But who will take those all important points and just how will Hull and Swansea's new managers fare in their first Premier League fixtures? Read on for the latest round of Premier League questions...
Can Dele Alli produce another Premier League double? (Tottenham v West Brom, Premier League Live, Saturday - Live on Sky Sports 1 HD from 11.30am)
What a season Dele Alli is having. After an impressive maiden campaign with Spurs last term following his move from MK Dons, he has overcome a quiet start to the current campaign to hit top form, scoring in his last four Premier League games.
The last three games have seen him score twice in each and he has already matched his 10 goal haul from last term, as well as becoming the fastest midfielder to reach 20 Premier League goals ahead of Paul Scholes, David Beckham, Frank Lampard and Steven Gerrard.
Alli has also scored in two of his last three appearances against West Brom, although six of the last nine top flight meetings between these two sides have ended with the points being shared, including a 1-1 draw in the last three fixtures.
Can the Clarets maintain their strong home form? (Burnley v Southampton - Saturday, 3pm)
Everyone enjoys their home comforts, and that is certainly true for Burnley this season. They have won 22 of their 23 points this season at Turf Moor with their one away point coming from the 0-0 draw at Manchester United in October.
That haul sees the Clarets have the highest percentage of points won at home (96 per cent) than any other team in the four professional English leagues and has helped Burnley record their best start to a Premier League campaign in their history.
This weekend, they come up against a Southampton side who are on a three-game losing streak in the top flight and another loss on Saturday would equal their worst-ever run in the league where they went four games without a win in December 2014.
How will Marco Silva fare in his first Premier League game? (Hull v Bournemouth - Saturday, 3pm)
A week into the job and new Hull manager Marco Silva will start to get to grips with the real job at the KCOM Stadium - Premier League survival. The Tigers are bottom of the table, three points from safety with a vastly inferior goal difference to 17th-placed Crystal Palace.
But after victory over fellow strugglers Swansea in the FA Cup on Saturday and a defeat to an in-form Manchester United in the EFL Cup semi-final first leg tie, there are positives to take from his first two games in charge.
Bournemouth are suffering a slight blip after crashing out of the FA Cup to Sky Bet League One side Millwall and failing to hold off Arsenal after racing into a 3-0 lead in their last league fixture, so Hull will be hoping for a positive start for their new man on Saturday.
Will Peter Crouch reach his Premier League century? (Sunderland v Stoke - Saturday, 3pm)
It has been a good couple of weeks for Peter Crouch, scoring in his last two Premier League outings against Chelsea and Watford and extending his contract with Stoke for another year.
He is now just two goals away from a century of Premier League goals and would join the likes of Alan Shearer, Ian Wright and Sky Sports' own Matt Le Tissier and Thierry Henry in the top flight's 100 club.
But despite their current occupation of the final relegation spot, Sunderland have lost just one of their last five games and are unbeaten in their last 14 home league games against the Potters.
Can Paul Clement start to turn the tide against the Gunners? (Swansea v Arsenal - Saturday, 3pm)
It was new manager v new manager in Paul Clement's first game in charge at Swansea against Hull but Silva came out on top with a 2-0 FA Cup win.
But after a full week of training and time to bed in with his new team, former Derby boss Clement will be hoping for signs of improvement from the league's second bottom side even if they face a tough opponent in fifth-placed Arsenal.
The Gunners have had a habit over the last few weeks of producing a comeback - doing so against Bournemouth and Preston respectively - and have never failed to score on a trip to the Liberty Stadium.
Can Troy Deeney continue his scoring form against Boro? (Watford v Middlesbrough - Saturday, 3pm)
Troy Deeney scored his 100th goal for Watford last month and has a good record of scoring against Middlesbrough, doing so in six of his last eight league games against them. He has only scored more league goals against Leeds (seven).
Watford haven't lost any of their last six league contests with Boro (W4 D2), last suffering defeat against them in October 2012 while the Teesside club have won only one of their last seven trips to Vicarage Road.
But it's not all doom and gloom for Aitor Karanka's men who have continued their defensive solidity from their promotion-winning Championship campaign, with only Spurs (14), Chelsea (15) and Manchester United (19) having conceded fewer goals in the Premier League this season than Boro (22).
Will Sam Allardyce get his first Crystal Palace win against his old club? (West Ham v Crystal Palace - Saturday, 3pm)
It hasn't been the happiest of returns to management for Sam Allardyce, with his Crystal Palace side yet to win under his leadership with two draws and two losses in all competitions.
Saturday's game presents the chance for the former England boss to pick up his first win against the club he managed for four years - West Ham. However, neither team boasts a particularly impressive London derby record.
The Hammers only win in a London derby this season came at Selhurst Park in October while Crystal Palace have lost all four of their meetings with fellow teams from the British capital this season.
Can Chelsea react after their winning run came to an end? (Leicester v Chelsea - Saturday, 5.30pm)
It was a disappointing evening for Chelsea against fierce rivals Tottenham last week as their 13-game winning run came to end, extinguishing their hopes of a record-breaking 14 victories.
While the Blues got straight back to winning ways in the FA Cup against Peterborough on Sunday, they will face a different task when the league resumes and can open up an eight-point gap over second-place Liverpool ahead of the Super Sunday fixtures.
After a disappointing first half of the season, Leicester are beginning to find a bit of form and pull away from the relegation zone, although they will be without key trio Riyad Mahrez, Islam Slimani and Daniel Amartey who are on international duty at the Africa Cup of Nations
Will John Stones make a winning return to Goodison Park? (Everton v Man City, Nissan Super Sunday - Live on Sky Sports 1 HD from 12.30pm)
It will be a first return to Everton for John Stones since his summer move to Man City and he will be hoping to stop his former side for going four games unbeaten in the Premier League.
The world's second most expensive defender moved to the Etihad for £47.5m in August after three seasons at Goodison Park with the clubs playing out a 1-1 draw earlier in the season during which City had two penalties saved by Maarten Stekelenburg.
A win on Sunday would mark a turn in fortunes for Everton, who are winless in their last seven Premier League games against City, with Pep Guardiola's men looking to maintain their push in the top four.
Live Nissan Super Sunday
Who will take bragging rights in the 50th Premier League meeting between Man Utd and Liverpool? (Nissan Super Sunday - Live on Sky Sports 1 HD from 3.30pm)
These two fierce rivals will meet for the 50th time in the top flight on Super Sunday this weekend, and both sides are hitting their stride in terms of form to set up a sizzler for their gold anniversary match.
Manchester United are on their longest unbeaten run this decade - going 15 matches without a loss in all competitions and winning the last nine - while Liverpool have not lost in six matches and have only lost twice all season.
Another tantalising thread to this fixture is the potential for Wayne Rooney to break the all-time scoring record for United after matching Sir Bobby Charlton's record against Reading in the FA Cup last week and to make history against a rival like Liverpool will surely be a huge incentive for the long-serving captain.