West Ham put positive Covid-19 test results for manager David Moyes and two players to the back of their minds as they put five goals past Hull City.
Defender Issa Diop and midfielder Josh Cullen were initially named in the team to face the League One Tigers.
But 15 minutes later the line-up was changed with both players omitted, and when the teams came out there was no sign of Moyes, with assistant Alan Irvine taking charge.
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A club statement subsequently read: "West Ham United can confirm that David Moyes, Issa Diop and Josh Cullen have returned positive tests for Covid-19.
"The club's medical team were informed of the test results as the team were at London Stadium preparing for this evening's Carabao Cup third-round tie against Hull City.
"The manager and both players immediately left the stadium and have returned home.
"All three, who are asymptomatic, will now follow Public Health England and Premier League guidelines and protocols.
"Everyone at West Ham United send their best wishes to David, Issa and Josh."
West Ham went on to say their measures and protocols around Covid-19 remain stringent and that they offered to test the Hull team ahead of the fixture, but City did not accept.
According to protocols Moyes, Diop and Cullen will have to isolate for 10 days, meaning they will miss Sunday's match at home to Wolves and the Carabao Cup fourth round.
This third-round tie went ahead as scheduled with Sebastien Haller and Andriy Yarmolenko both scoring twice and Robert Snodgrass also on target in a comfortable victory.
Snodgrass opened the scoring against his former cub when he volleyed in a cross from Yarmolenko.
Manuel Lanzini fizzed a shot narrowly wide before Haller made it 2-0 at half-time from Yarmolenko's lay-off.
Yarmolenko added the third from the penalty spot after a foul on Haller.
Although Mallik Wilks pulled one back, Haller and Yarmolenko struck again in stoppage time as West Ham earned a fourth-round trip to Everton or Fleetwood.