Liverpool expect Divock Origi to feature after being forced off against West Ham with cramp in midweek, while Adam Lallana has also recovered from a recent virus.
However, Sadio Mane, James Milner (both hamstring) and Xherdan Shaqiri (calf) are still sidelined with injury.
Image:Liverpool expect Divock Origi to be fit to feature against the Saints
Southampton manager Ralph Hasenhuttl has confirmed Stuart Armstrong will be absent for two to three weeks through injury, with new loan signing Kyle Walker-Peters also not in the squad after his move from Tottenham.
Yan Valery and Jannick Vestergaard are back in training after injury and available for selection.
Follow the match in our dedicated live blog, while highlights will also be published on the Sky Sports digital platforms and the Sky Sports Football YouTube channel at 5.15pm.
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FREE TO WATCH: Highlights from Southampton's win against Crystal Palace in the Premier League
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FREE TO WATCH: Highlights from Liverpool's win at West Ham in the Premier League
Liverpool have won their last five Premier League games against Southampton, scoring 13 goals and conceding just two in this run.
Southampton have won three of their last 30 away top-flight matches against Liverpool (D10 L17) and are winless in five (D2 L3) since winning 1-0 in September 2013.
Liverpool have won their last 19 Premier League home games - only Manchester City have ever had a longer such run in the competition (20 between March 2011-March 2012). Indeed, in top-flight history only four teams have ever won 20+ consecutive home league games, with Liverpool holding the outright record (21 between January-December 1972).
Southampton have won just four of their 40 away Premier League matches on Merseyside against Everton and Liverpool (D11 L25), winning none of their last 11 visits (D4 L7).
As well as being unbeaten in 52 Premier League home games, Liverpool have scored in each of their last 27 at Anfield in the competition. They last scored in more in a row in the top-flight between May 1967 and February 1969 (38 games).
Southampton have won 65% of their Premier League points this season away from home (20/31) - in the history of the competition, only Crystal Palace in 1997-98 (67%) have won a higher share on the road over a full season.
Southampton have won their last four Premier League away games - only once in their league history have Saints won five in a row on the road, doing so between April-August 2011 between League One and the Championship.
Liverpool's Mohamed Salah has been directly involved in six goals in five Premier League appearances against Southampton (5 goals, 1 assist), scoring three goals in two games at Anfield.
Southampton's top scorer this season Danny Ings scored in Saints' 1-2 loss against Liverpool in August. Only two players have scored home and away in the same Premier League season against Liverpool having previously played for the Reds in the competition - Dean Saunders in 1992-93 and Jonjo Shelvey in 2013-14.
No player has scored more home Premier League goals this season than Liverpool's Mohamed Salah (10). He's just the second player to reach double figures at Anfield in three consecutive Premier League seasons, after Robbie Fowler (1994-95 to 1996-97)
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A look ahead to a busy weekend of Premier League action, where Manchester City take on Tottenham and Manchester United host Wolves
Charlie's prediction
The Liverpool machine just rolls on. I did think they looked a little on edge against Wolves but they got through again and then strolled through at West Ham with minimum stress. The graft and determination is there and a break is just around the corner. They will not worry about the FA Cup scenario and have some time off. Southampton have been impressive. Ralph Hasenhuttl is brilliant - I did not see the need to get rid of him or ever think he was under any pressure in his position. He has been courageous and he has the energy back in Southampton. He has Danny Ings, Nathan Redmond and Shane Long all playing well for him. I think he may go with a back five for the Liverpool match - who can blame him? Saints are dangerous, but when Liverpool pin teams in, they do not let you off the hook and it is the wide men that do that to you. There is no relief through the midfield either. I can't see this machine faltering. I am so impressed.
Sadio Mane is a doubt for Liverpool's clash with Southampton but 93.7 per cent of Super 6 players are backing Liverpool to score two or more, regardless. What scoreline takes your fancy? Play Super 6 for free.
